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The publications listed below are directly related to the project.

Journal papers

J. Picó, F. Garelli, H. De Battista, R.J. Mantz, Geometric invariance and reference conditioning for control of overflow metabolism, Journal of Process Control, 19 (10), pp. 1617-1626, 2009.



J. Picó, H. De Battista, F. Garelli,  Smooth sliding-mode observers for specific growth rate and substrate from biomass measurement, Journal of Process Control, 19 (10), pp. 1314-1323, 2009.



H. De Battista, J.Picó, E. Picó-Marco, Globally Stabilizing Control of Fed-Batch Processes with Haldane Kinetics Using Growth Rate Estimation Feedback, Journal of Process Control, 16, pp. 865-875, 2006.



H. De Battista, E. Picó-Marco, J.Picó, On 'Feedback Stabilization of Fed-Batch Bioreactors: Non-Monotonic Growth Kinetics', Biotechnology Progress, American Chemical Society Publications, Vol.21, No. 3, pp.651-652, 2005.



E. Picó-Marco, J.Picó, H. De Battista, Sliding Mode Scheme for Adaptive Specific Growth Rate Control in Biotechnological Fed-batch Processes, International Journal of Control, Taylor&Francis, Vol.78, No.2, pp.128-141, 2005.




Books and Book chapters


Picó, J., Picó-Marco, E., Navarro,J.L., De Battista,H. Control of fedbatch bioreactors. Part I. in Nonlinear and adaptive control: theory and algorithms for the user, A. Astolfi (London) Editor, Imperial College Press, pp.207-238, 2006.


The publications listed below are indirectly related to the project. Thus, publications in the fields of control and biotechnology have been included.

Journal papers


  1. F. Llaneras, A. Sala, J. Picó, A possibilistic framework for constraint-based metabolic flux analysis, BMC Systems Biology, Vol. 3:79, 2009.
  2. J. Camacho, J. Picó,A. Ferrer , On-line monitoring of batch processes based on PCA: Does the modelling structure matter?, Analytica Chimica Acta, Vol. 642(1-2), pp. 59-68, 2009.


  1. F. Garelli, R.J. Mantz y H. De Battista, Collective sliding mode technique for multivariable bumpless transfer. Industrial & Engineering Chemistry Research, ACS Publications, (47), 2721-2727. 2008.
  2. J. Camacho, J. Picó, A. Ferrer, Multi-Phase Analysis Framework for handling Batch process Data, Journal of Chemometrics, 11(22), pp. 632-643, Wiley, 2008.
  3. F. Llaneras, J. Picó, Stoichiometric Modelling of Cell Metabolism, Journal of Bioscience and Bioengineering, Vol. 105 (1), pp. 1-11,2008.
  4. J. Camacho, J. Picó, A. Ferrer, Bilinear modelling of batch processes. Part I: theoretical discussion, Journal of Chemometrics, 5(22), pp. 299-308, Wiley, 2008.
  5. J. Camacho, J. Picó, A. Ferrer, Bilinear Modelling of Batch Processes. Part II: A comparison of PLS soft-sensors, Journal of Chemometrics, 10(22), pp. 533-547, Wiley, 2008.



  1. F. Garelli, R.J. Mantz y H. De Battista, Sliding mode compensation to preserve dynamic decoupling of stable systems. Chemical Engineering Science, Elsevier, (62), 4705-4716. 2007.
  2.  F. Llaneras, J. Picó, An Interval Approach for Dealing with Flux Distributions and Elementary Modes Activity Patterns, Journal of Theoretical Biology, vol. 246, pp.290-308, Springer Verlag
  3. J. Camacho, J. Picó, A. Ferrer, Self-tuning run to run optimization of fed-batch processes using unfolded-PLS,  AIChE, vol. 53, no. 7, pp. 1789-1803, American Chemical Society
  4. F. Llaneras, J. Picó   A procedure for the estimation over time of metabolic fluxes in scenarios where measurements are uncertain and/or insufficient, BMC Bioinformatics, 8:421, 2007.
  5. F. Llaneras, M. Tortajada, J. Picó, Structural analysis of metabolic pathways applied to heterologous protein production with Pichia pastoris. Journal of Biotechnology, 131 issue 2S, pp. 209, 2007.
  6. J. C. Dehesa, J. Picó, J. Bondia, E. Picó-Marco, Robust posibilistic control of nonlinear flat systems. Journal of Biotechnology, 131 issue 2S, pp. 105, 2007.


  1. F. Garelli, R.J. Mantz y H. De Battista, Limiting interactions in decentralized control of MIMO systems. Journal of Process Control, Elsevier, (16), 473-483. 2006.
    This article was 5th in the TOP 25 SCIENCE DIRECT HOT PAPERS, from  01/2006 – 03/2006.
  2. F. Garelli, R.J. Mantz y H. De Battista, Partial decoupling of non-minimum phase processes with bounds on the remaining coupling. Chemical Engineering Science, Elsevier,  (61), 7706-7716. 2006.
  3. J.L. Díez,  A. Sala, J.L. Navarro, Target-shaped possibilistic clustering applied to local-model identification, Engineering Applications of Artificial Intelligence, Vol.19, pp. 201 – 208, 2006.
  4. E. Picó-Marco, J.L. Navarro, J.M. Bruno-Bárcena, A closed loop exponential feeding law: invariant and global stability analysis, Journal of Process control, vol.16, no.4, pp.395-402, 2006.
  5. Camacho,J., Picó,J. Multi-phase Principal Components Analysis for Batch Processes Modelling,  Chemometrics and Intelligent Laboratory Systems, vol.81, pp.127-136, 2006.
  6. J. Bondia, A. Sala, J. Picó, M.A. Sainz, Controller design under fuzzy pole-placement specifications: an interval arithmetic approach, IEEE Transactions on Fuzzy Systems, 14(6), pp. 822-836, 2006.
  7. Camacho,J., Picó,J. Monitorización de procesos por lotes a través de PCA multifase, Revista Iberoamericana de Automática e Informática Industrial, 3(3), pp. 78-91, 2006.
  8. Camacho,J., Picó,J. Online Monitoring of Batch Processes using phase Principal Components Analysis, Journal of Process Control, 16(10), pp. 1021-1035, 2006.   


  1. C. Tarín, E. Teufel, J. Picó, J. Bondia, H.-J. Pfleiderer. Comprehensive pharmacokinetic model of insulin Glargine and other insulin formulations, IEEE Transactions on Biomedical Engineering, pp.1994-2005, Vol.12, 2005.
  2. Picó,J., Sánchez,A., Bondia,J., Escudero,D., Torregrosa,A., Correcher, C., Intelligent robotic cell for trencadís mosaics manufacturing, IEEE Trans. on Systems, Man and Cybernetics, special issue Pattern recognition for autonomous manipulation in robotic systems, Vol. 35, no. 1, pp.75-87, 2005.


  1. E.Teufel, C.Tarín, J.Picó, J.Bondia, H.Pfleiderer, Integration of diary, food database and insulin dosage aid for type 1 diabetic patients on a PDA, BIOMEDIZINISCHE TECHNIK, Vol. 49 No. 2 , pp. 218 – 219, 2004.
  2. Bondia,J., Picó,J. Application of functional intervals to the response evaluation of LTI systems with fuzzy input,  Reliable Computing, Kluwer Academic Publishers, Vol. 10, no.5, pp.369-387, 2004.


  1. Bondia,J., Picó,J. Analysis of linear systems with fuzzy parametric uncertainty, Fuzzy Sets and Systems, vol. 135, pp. 81-121, 2003.
  2. Bondia,J., Picó,J. A geometric approach to robust performance of parametric uncertain systems. Int. Journal of Robust and Nonlinear Control, vol.13, no.14, pp.1271-1283, 2003.


  1. Navarro, J., Picó, J., Bruno, J., Picó-Marco, E., and Vallés, S., On-line method and equipment for detecting, determining the evolution and quantifying a microbial biomass and other substances that absorb light along the spectrum during the development of biotechnological processes.
    Patent ES20010001757, (2001), EP20020751179, (2004), US Patent 10/757,717.